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Search Results for " brain-derived neurotrophic factor "

Targets Recommended: Trk receptor

9

抑制剂 & 化合物

1

天然产物

1

化合物库

6

重组蛋白

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Cat. No.	Product Name
L6750	活血化瘀中药单体库		580 compounds
	580种来源于常见活血化瘀中药的单体化合物，是药物开发、药理研究等领域的有效工具。

化合物库

活血化瘀中药单体库

Cat.No: L6750

Compounds: 580

Cat. No.	Product Name	Target	Signaling Pathways
T7568	LM22A-4	Trk receptor	Tyrosine Kinase/Adaptors
	LM22A-4 是特异性的tyrosine kinase receptor B 激动剂，常用于研究神经系统疾病。
T8779	HBT1	GluR	Neuroscience
	HBT1 是一种 AMPA 受体增强剂，可诱导脑源性神经营养因子 (BDNF) 的产生，并且在原代神经元中几乎没有激动作用。 HBT1 以谷氨酸依赖的方式与 AMPA-R 的配体结合结构域结合。
T26993	CGP 56999A CGP56999A,CGP-56999A
	CGP 56999A is an antagonist of GABA(B) receptor, it enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum.
T63346	TRK-IN-18
	TRK-IN-18 是 TRK 的有效抑制剂。其中原肌球蛋白相关激酶 (Trks) 是一种受体酪氨酸激酶家族，由神经营养因子激活，神经营养因子是一组可溶性生长因子，包含神经生长因子 (NGF)、脑源性神经营养因子 (BDNF) 和神经营养因子-3 (NT-3)，以及神经营养因子-4/5 (NT-4/5)。TRK-IN-18 表现出对癌症疾病的研究潜力。
T62561	TRK-IN-17
	TRK-IN-17 是一种 TRK 的有效抑制剂。其中原肌球蛋白相关激酶 (Trks) 是受体酪氨酸激酶家族成员，由神经营养因子激活。神经营养因子是一组可溶性生长因子，包括神经生长因子 (NGF)、脑源性神经营养因子 (BDNF) 和神经营养因子-3 (NT-3)，以及神经营养因子-4/5 (NT-4/5)。TRK-IN-17 具有潜力进行癌症疾病的研究。
T37167	Reduced Haloperidol
	Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing ...
T81571	PACAP (1-38) free acid TFA
	PACAP (1-38) free acid TFA，一种内源性神经肽，能有效促进胃窦运动，增强体液蛋白分泌，同时抑制胃泌素释放。此外，它刺激血管活性肠肽、胃泌素释放肽和P物质的释放，并通过RACK1增强N-甲基-D-天门冬氨酸受体功能及脑源性神经营养因子表达。
T72227	PI3K/Akt/CREB activator 1
	PI3K/Akt/CREB activator 1 是一种口服有效的PI3K/Akt/CREB 的激活剂。PI3K/Akt/CREB activator 1 通过 PI3K/Akt/CREB 通路上调脑源性神经营养因子，促进神经元增殖，诱导 Neuro-2a 细胞分化成神经元样形态，加速海马原代神经元轴突-树突极化的建立。PI3K/Akt/CREB activator 1 可用于血管性痴呆 (VaD) 的研究。
T81572	PACAP (1-38) free acid
	PACAP (1-38) free acid 是一种具有多重生物功能的内源性神经肽，主要作用包括刺激胃窦运动、增进体液蛋白分泌、抑制胃泌素分泌，以及促进血管活性肠肽、胃泌素释放肽和P 物质的释放。此外，PACAP (1-38) free acid 通过与RACK1互作，可以增强N-甲基-D-天门冬氨酸受体的功能并促进脑源性神经营养因子的表达。

化合物

Cat.No: T7568

Target: Trk receptor

Cat.No: T8779

Target: GluR

Cat.No: T26993

Synonym: CGP56999A,CGP-56999A

Cat.No: T63346

Cat.No: T62561

Reduced Haloperidol

Cat.No: T37167

PACAP (1-38) free acid TFA

Cat.No: T81571

PI3K/Akt/CREB activator 1

Cat.No: T72227

PACAP (1-38) free acid

Cat.No: T81572

Cat. No.	Product Name	Target	Signaling Pathways
T4779	4-Methylcatechol p-Methylcatechol,3,4-二羟基甲苯,Homocatechol,4-methylbenzene-1,2-diol,3,4-Dihydroxytoluene	Others; Endogenous Metabolite	Metabolism; Others
	4-Methylcatechol (3,4-Dihydroxytoluene) 是 p-toluate 的代谢物，它是 Catechol 2,3-Dioxygenase 的自杀性底物抑制剂。

天然产物

4-Methylcatechol

Cat.No: T4779

Synonym: p-Methylcatechol,3,4-二羟基甲苯,Homocatechol,4-methylbenzene-1,2-diol,3,4-Dihydroxytoluene

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05510	BDNF Protein, Mouse, Recombinant (His) brain-derived neurotrophic fa...	Mouse	HEK293 Cells
	BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth,...
TMPJ-00135	BDNF Protein, Human/Murine/Rat, Recombinant BDNF,Abrineurin,Brain-Derived Neurotro...	Human,Mouse,Rat	E. coli
	Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ...
TMPJ-00134	pro-BDNF Protein, Human, Recombinant Brain-Derived Neurotrophic Fa...	Human	E. coli
	The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regul...
TMPH-03251	BDNF Protein, Rat, Recombinant (His) Brain-derived neurotrophic fa...	Rat	E. coli
	BDNF Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 16.3 kDa and the accession number is P23363.
TMPJ-01469	NGF Protein, Human, Recombinant (E. colli) NGFB,神经生长因子,β-NGF,NGF,Beta-Nerve Growth Factor,β-Ne...	Mouse	E. coli
	NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an impo...
TMPY-04069	Neurotrophin 3 Protein, Human, Recombinant NGF2,HDNF,NT-3,neurotrophin 3,NGF-2,NT3	Human	E. coli
	NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NTF3 is a key mediator of neuronal development during the early neurogenic period. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. ...

重组蛋白

BDNF Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05510

Species: Mouse

Expression System: HEK293 Cells

BDNF Protein, Human/Murine/Rat, Recombinant

Cat.No: TMPJ-00135

Species: Human,Mouse,Rat

Expression System: E. coli

pro-BDNF Protein, Human, Recombinant

Cat.No: TMPJ-00134

Species: Human

Expression System: E. coli

BDNF Protein, Rat, Recombinant (His)

Cat.No: TMPH-03251

Species: Rat

Expression System: E. coli

NGF Protein, Human, Recombinant (E. colli)

Cat.No: TMPJ-01469

Species: Mouse

Expression System: E. coli

Neurotrophin 3 Protein, Human, Recombinant

Cat.No: TMPY-04069

Species: Human

Expression System: E. coli

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